Browsing by Author "McKerrow, James H."
Now showing items 1-14 of 14
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4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency
Calvet, C. M. et al. | Date Issued: 2014 -
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection
Calvet, Claudia Magalhaes et al. | Date Issued: 2017 -
Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms
Rebello, Karina M. et al. | Date Issued: 2018 -
Binding Mode and Potency of N‑Indolyloxopyridinyl-4- aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51
Vieira, Debora F. et al. | Date Issued: 2014 -
A Comparative Chemogenomics Strategy to Predict Potential Drug Targets in the Metazoan Pathogen, Schistosoma mansoni
Caffrey, Conor R. et al. | Date Issued: 2009 -
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)
Debnath, Anjan et al. | Date Issued: 2017 -
Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of leishmania infection
Kavouris, John A. et al. | Date Issued: 2023 -
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
Gunatilleke, Shamila S. et al. | Date Issued: 2012 -
Identification of novel genes and proteoforms in Angiostrongylus costaricensis through a proteogenomic approach
Silva, Esdras Matheus Gomes da et al. | Date Issued: 2022 -
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole
Calvet, Claudia Magalhães et al. | Date Issued: 2020 -
Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways
Wozniak, Jacob M. et al. | Date Issued: 2020 -
Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast
Ottilie, Sabine et al. | Date Issued: 2017 -
Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents
Choi, Jun Yong et al. | Date Issued: 2013 -
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases: rhodesain; cruzain and Schistosoma mansoni cathepsin B1
Fonseca, Nayara Cristina et al. | Date Issued: 2015